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Long intergenic non-protein coding RNA 428 (LINC00428)
- Target
- LINC00428
- Molecular classification
- Long non-coding RNA, Long intergenic noncoding RNA (lincRNA)
01
Overview
Long intergenic non-protein coding RNA 428 (LINC00428) is a cytoplasmic lincRNA transcript that regulates gene expression and cellular behaviors primarily by acting as a molecular sponge for microRNAs. In breast cancer, LINC00428 (also named Lnc-408 in some literature) sequesters miR-654-5p, relieving microRNA-mediated repression of Lim domain kinase 1 (LIMK1), a protein involved in cytoskeletal actin polymerization and cell invasion. Enhanced expression of LINC00428 promotes invasive and metastatic properties in breast cancer cells, partly by upregulating LIMK1, MMP2, ITGB1, and COL1A1 through the CREB pathway. Its disease association, especially in promoting aggressive cancer phenotypes, makes LINC00428 an attractive but complex target for research into diagnostics and therapeutics.
- Other names
- LINC00428Lnc-408
02
Mechanism of action
Therapeutic inhibition using RNA interference, antisense oligonucleotides, or CRISPR; Indirect targeting through modulation of downstream microRNAs or related signaling molecules
03
Biological functions
Regulation of gene expressionMicroRNA sponge activityModulation of cytoskeletal organizationPromotion of cell invasion and metastasis
04
Disease associations
Cancerbreast cancer
05
Safety considerations
Off-target effects of RNA-based therapeuticsRisks associated with altering global lncRNA networks, which may affect multiple cellular processes
06
Biomarkers
Overexpression in breast cancer cells can serve as a molecular biomarker for prognosis and stratificationHigh LINC00428 expression linked to epithelial-mesenchymal transition (EMT) and metastasis in breast cancer
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