Long intergenic non-protein coding RNA 441 (LINC00441)

Long intergenic non-protein coding RNA 441 (LINC00441, also known as RB1-DT, ncRNA-RB1) is a divergent long non-coding RNA transcribed in the opposite direction from the RB1 gene locus. It is implicated in the regulation of cell proliferation and oncogenesis primarily through epigenetic silencing of the tumor suppressor RB1 in cancers such as hepatocellular carcinoma, gastric cancer, and cervical cancer. The gene product operates mainly by recruiting DNA methyltransferases to target promoters, thus repressing tumor suppressor gene transcription, and, in some contexts, by sequestering regulatory microRNAs. Aberrant upregulation of LINC00441 is frequently associated with tumor progression. Although not an enzyme, receptor, or classically druggable protein, LINC00441 represents a promising candidate for RNA-based therapeutic strategies and as a biomarker for specific malignancies.

Other names

RB1-DTncRNA-RB1Long intergenic non-protein coding RNA 441LINC00441

Not applicable directly, but mechanisms described for LINC00441 include - Recruitment of DNA methyltransferases to promoter regions of tumor suppressors such as RB1, leading to epigenetic silencing - MicroRNA sponging—acting as a ceRNA to sequester specific microRNAs, modulating downstream gene expression