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Target intelligence / Profile preview
Long intergenic non-protein coding RNA 459 (LINC00459)
- Target
- LINC00459
- Molecular classification
- Long non-coding RNA (lncRNA), Long intergenic non-coding RNA (lincRNA)
01
Overview
LINC00459 is a long intergenic non-coding RNA located on chromosome 13q21.31 that functions in cancer biology primarily by acting as a competing endogenous RNA for miR-218. By sequestering miR-218, LINC00459 increases DKK3 expression, which inhibits cell proliferation, promotes apoptosis, and reduces the invasive capacity of melanoma cells. Decreased expression of LINC00459 correlates with poor patient outcomes, and upregulation in cellular models slows tumor growth and metastasis, suggesting value as both a biomarker and a therapeutic target.
- Other names
- LINC00459
02
Mechanism of action
LINC00459 acts as a ceRNA, binding and sequestering miR-218, which in turn increases expression of the dickkopf-related protein 3 (DKK3), leading to anti-proliferative effects against melanoma cells
03
Biological functions
Cell proliferation inhibitionCell cycle regulationPromotion of cell apoptosisSuppression of cell invasionFunctioning as a competing endogenous RNA (ceRNA), sponging microRNAs such as miR-218
04
Disease associations
Cancer (specifically, inhibits melanoma proliferation and invasion)
05
Safety considerations
No specific safety concerns or therapeutic challenges have been described for targeting LINC00459, as there are no clinically studied drugs that target this RNA
06
Biomarkers
LINC00459 expression levels serve as an independent biomarker for overall survival (OS) and progression-free survival (PFS) in patients with melanoma
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