Long intergenic non-protein coding RNA 472 (LINC00472)

Long intergenic non-protein coding RNA 472 (LINC00472) is a long non-coding RNA gene located on chromosome 6q13. It is transcribed as a non-protein coding transcript and has been implicated in a diverse range of biological functions, particularly as a tumor suppressor in multiple cancer types including breast, lung, liver, and others. LINC00472 also plays significant roles in non-cancer diseases, such as neuropathic pain, osteoarthritis, atherosclerosis, and liver injury. Mechanistically, LINC00472 acts as a molecular sponge for microRNAs, modulates key cellular signaling pathways like NF-κB and p53, and regulates cell proliferation, apoptosis, inflammation, and extracellular matrix degradation. In disease contexts, it is dysregulated and contributes both as a potential therapeutic target and as a biomarker for diagnosis, prognosis, and drug sensitivity, especially in cancer and chronic inflammatory conditions[1][2][3][4]

Other names

C6orf155PEXFP53RRAFLJ13189dJ288M22.3p53 related lncRNApluripotency exit factor

Not directly drug-targeted; acts primarily via modulation of gene expression, miRNA sponging (e.g., miR-300, miR-361-5p, miR-23a-3p), and regulation of signaling pathways (NF-κB, p53, CCL22) [1][2][4]