Long intergenic non-protein coding RNA 482 (LINC00482)

Long intergenic non-protein coding RNA 482 (LINC00482) is a human long non-coding RNA (lncRNA) gene found on chromosome 17 and is also referenced by the aliases C17orf55 and FLJ39421[1][3][7]. As a lncRNA, it does not encode a protein but instead has regulatory functions at the RNA level. LINC00482 is primarily localized in the cytoplasm and is implicated in various cellular processes such as cell proliferation, migration, apoptosis, inflammation, and angiogenesis[1][2][4]. In cancer biology, LINC00482 has been shown to promote tumor growth, progression, and metastasis, particularly in prostate cancer and bladder cancer. Mechanistically, it acts as a competing endogenous RNA (ceRNA), sponging microRNAs like miR-2467-3p, thereby modulating signaling pathways such as Wnt/β-catenin and activating transcription factors including FOXA1[2][4]. Elevated levels of LINC00482 correlate with aggressive tumor phenotypes and poor outcomes in certain cancers, suggesting it may serve as both a biomarker and a potential therapeutic target, though it is not currently recognized as a direct drug target or classical receptor/enzyme[2][4][7].

Other names

C17orf55FLJ39421Putative uncharacterized protein encoded by LINC00482

Acts as a sponge for microRNAs (e.g., miR-2467-3p); Modulates Wnt/β-catenin signaling; Interacts with transcription factors (e.g., FOXA1); Regulates expression of matrix metalloproteinases (e.g., MMP15)