Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Long intergenic non-protein coding RNA 487 (LINC00487)
- Target
- LINC00487
- Molecular classification
- Long non-coding RNA, Non-protein coding RNA, lncRNA
01
Overview
Long intergenic non-protein coding RNA 487 (LINC00487) is a long non-coding RNA gene located at chromosome 2 in humans and characterized by its lack of protein-coding potential[1][3][5]. LINC00487 participates in key regulatory networks affecting immune signaling, cell adhesion, epigenetic regulation, and immune cell activation[2][4]. It has been identified as a protective factor in hepatocellular carcinoma and serves as a prognostic biomarker in diffuse large B-cell lymphoma, where its expression is associated with favorable outcome[4]. LINC00487 is also involved in the gene-regulatory processes relevant for systemic lupus erythematosus and other immune-related pathologies[2]. It is not currently recognized as a direct therapeutic target, nor are there approved drugs that interact with it[1][3][5].
- Other names
- FLJ42418AC079923.1LINC00487
02
Mechanism of action
Not applicable, as LINC00487 is not targeted by existing drugs
03
Biological functions
Regulation of immune responseRegulation of T-cell activation and proliferationRegulation of immune cell chemotaxis and interferon signalingRegulation of leukocyte adhesion and co-stimulationEpigenetic regulation (via ceRNA network interactions)
04
Disease associations
Cancer (protective factor in hepatocellular carcinoma and associated with diffuse large B-cell lymphoma prognosis)Immune diseases (associated with gene networks in systemic lupus erythematosus)Potential biomarker in various solid tumors and lymphomas
05
Safety considerations
No notable safety concerns or therapeutic challenges specifically described for modulation of LINC00487 itself
06
Biomarkers
Prognostic biomarker in hepatocellular carcinoma (protective factor)Prognostic and stratification marker in diffuse large B-cell lymphoma (DLBCL)Marker for immune infiltration and potential response to immune therapy in DLBCL
Beyond the preview
Go deeper on Long intergenic non-protein coding RNA 487 (LINC00487).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Long intergenic non-protein coding RNA 487 (LINC00487).