Long intergenic non-protein coding RNA 491 (LINC00491)

Long intergenic non-protein coding RNA 491 (LINC00491) is a cytoplasmic long non-coding RNA transcribed from chromosome 5q21.1[1][6]. It is characterized as a competing endogenous RNA (ceRNA) that interacts with and "sponges" specific microRNAs, such as miR-145 in colon adenocarcinoma and miR-324-5p in non-small cell lung cancer, leading to increased expression of oncogenic proteins such as SERPINE1 and SP1[2][4][6]. LINC00491 is significantly upregulated in various cancers and promotes proliferation, migration, and invasion of cancer cells, while its knockdown increases apoptosis and reduces malignant phenotypes[3][5][6]. This molecule is increasingly studied as both a therapeutic target and a prognostic biomarker, though its functions suggest caution for safety given the complexity of lncRNA networks[4][6].

Other names

BC008363CTD-2340E1.3LINC00491

Acts as a competing endogenous RNA to "sponge" specific microRNAs (e.g., miR-145, miR-324-5p), leading to upregulation of target oncogenes (e.g., SERPINE1, SP1)