Long intergenic non-protein coding RNA 501 (LINC00501)

Long intergenic non-protein coding RNA 501 (LINC00501) is a nuclear-localized long non-coding RNA implicated in the regulation of cell proliferation, apoptosis, migration, invasion, and metastasis, particularly in cancers such as non-small cell lung cancer and gastric cancer[2][3][4]. LINC00501 functions mainly as a competitive endogenous RNA (ceRNA), sequestering specific microRNAs to derepress target oncogenes (such as HMGB1 and SLUG)[2][4]. It is also involved in major tumor-related signaling pathways (TGF-beta, WNT, mTOR, MAPK)[3], and its upregulation by epigenetic mechanisms (e.g., H3K27 acetylation mediated by P300) further promotes oncogenic processes[4]. High expression levels of LINC00501 serve as prognostic and diagnostic biomarkers, correlating with metastasis and recurrence in gastric cancer[3][4]. Experimental evidence supports the therapeutic targeting of LINC00501, either directly or via its regulatory axes (e.g., by inhibiting P300), to attenuate tumor progression[4].

Other names

LINC00501Long intergenic non-protein coding RNA 501

Modulation of gene transcription (transactivation of SLUG through chromatin interaction); Competitive endogenous RNA (ceRNA) mechanism (sponging of microRNAs); Modulation of signaling pathways (TGF-beta, mTOR, MAPK, WNT associated with tumor growth and progression)