Long intergenic non-protein coding RNA 511 (LINC00511)

LINC00511 is a long intergenic non-protein coding RNA encoded on chromosome 17 (GRCh38/hg38) and is implicated in the regulation of gene expression through multiple mechanisms, primarily by serving as a competing endogenous RNA and miRNA sponge. It promotes proliferation, invasion, migration, tumor stemness, and chemoresistance in a broad spectrum of cancers. LINC00511 activates key oncogenic signaling pathways including Wnt/β-catenin, epigenetically represses tumor suppressors via interactions with chromatin modifiers, and modulates transcription factors including VDR. LINC00511 is established both as a cancer biomarker and as a promising therapeutic target for future drug development, with emerging research also suggesting it might encode functional small peptides with unique oncogenic properties.

Other names

onco-lncRNA-12LCAL5lung cancer associated lncRNA 5ERRLR01HI-LNC75HILNC75LUCAIR1RASONSLNCRSLNCR1RAS-ONSRA-like non-coding RNAhuman islet long non coding RNA 75lung cancer intergenic RNA 1LINC00673

LINC00511 acts as a competing endogenous RNA (ceRNA) by sponging miRNAs including miR-625, miR-185-3p, and miR-15a-3p, thereby affecting the expression of oncogenes (e.g., CCND1, E2F1). It also performs epigenetic regulation by interacting with chromatin modifiers like EZH2 for histone methylation. Furthermore, it engages in transcriptional regulation by modulating transcription factor activity, including the vitamin D receptor pathway. LINC00511 also modulates signaling pathways, notably activating the Wnt/β-catenin pathway, which impacts cell proliferation and cancer stemness.