Long intergenic non-protein coding RNA 517 (LINC00517)

LINC00517 (Long intergenic non-protein coding RNA 517) is a long non-coding RNA gene located on human chromosome 14 (C14orf26) that encodes an RNA transcript but not a protein. It belongs to the lincRNA class, meaning its locus does not overlap protein-coding genes and its function is primarily regulatory at the RNA level. LINC00517 has been studied for its possible involvement in cancer biology, specifically in triple-negative breast cancer and ovarian cancer, where changes in its expression correlate with disease status and treatment response. The molecular mechanisms and biological functions of LINC00517 specifically remain to be established in detail. As a lincRNA, it may participate in chromatin remodeling, transcriptional or epigenetic regulation, but detailed mechanistic roles have not been described. Currently, it is not a validated therapeutic target and no drugs are known to interact directly with LINC00517.

Other names

C14orf26LINC00517ENSG00000259091 (Ensembl gene ID)NONHSAG014755.2 (NONCODE identifier)

Not established. No drug mechanism reported as directly targeting LINC00517. Changes in transcript expression have been reported after drug treatment (e.g., ivermectin), but these are not established direct mechanisms of action.