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Target intelligence / Profile preview
Long intergenic non-protein coding RNA 554 (LINC00554)
- Target
- LINC00554
- Molecular classification
- long non-coding RNA, lincRNA
01
Overview
Long intergenic non-protein coding RNA 554 (LINC00554), also known as lncZic2, is a human gene classified as a long non-coding RNA (lncRNA)[1][3][5][7][9]. LINC00554 is implicated in the regulation of cancer cell proliferation, metastasis, and self-renewal, functioning as a tumor suppressor in epithelial ovarian cancer and hepatocellular carcinoma[2][3]. Lower expression levels of LINC00554 are associated with advanced disease state and poorer prognosis in ovarian and liver cancers, making it a proposed diagnostic and prognostic biomarker[2]. Mechanistically, LINC00554 is reported to act through the Akt/mTOR signaling pathway and regulate key substrates involved in cell survival and migration. There are no currently known therapeutic drugs directly targeting LINC00554, though it is considered a promising research target for cancer diagnostics and intervention[2][3][9].
- Other names
- lncZic2LINC00554
02
Mechanism of action
Modulation of cell proliferation/metastasis via pathways such as Akt/mTOR, regulation of protein kinase C substrates MARCKS and MARCKSL1
03
Biological functions
Cell proliferationCell self-renewalTumor suppressionRegulation of metastasis
04
Disease associations
Cancer (notably hepatocellular carcinoma, epithelial ovarian cancer, esophageal cancer, cervical cancer)
05
Biomarkers
Diagnostic/prognostic biomarker for epithelial ovarian cancer (low levels correlate with advanced stage, metastasis, and poor survival)potential biomarker in hepatocellular carcinoma
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