Long intergenic non-protein coding RNA 559 (LINC00559)

Long intergenic non-protein coding RNA 559 (LINC00559) is a gene that encodes a long non-coding RNA of more than 200 nucleotides, transcribed from intergenic regions and not overlapping any known protein-coding genes. LINC00559 functions as a regulatory molecule involved in chromatin remodeling and the regulation of gene transcription, notably influencing cancer cell growth, colony formation, and cell cycle progression. Specifically, LINC00559 interacts with chromatin remodeling factors (such as SMARCA6) and transcription factors (such as ZBTB18) to regulate tumor suppressor gene expression, facilitating tumorigenesis, especially in lung cancer models. LINC00559 and similar lincRNAs are under investigation as both potential therapeutic targets and biomarkers in oncology, given their disease- and tissue-specific expression patterns and regulatory influence on cancer-relevant pathways. However, specific clinical drug targeting of LINC00559 is still experimental, and no approved drugs selectively modulate its function; FX1 is an example of a molecule that disrupts relevant protein-lncRNA complexes in preclinical models.

Other names

LINC00559long intergenic non-protein coding RNA 559

Disruption of protein–lncRNA complexes (e.g., FX1 inhibits the SMARCA6-LINC00559-ZBTB18 complex to repress cancer progression)