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Long intergenic non-protein coding RNA 562 (LINC00562)
- Target
- LINC00562
- Molecular classification
- Long non-coding RNA, Long intergenic non-coding RNA
01
Overview
Long intergenic non-protein coding RNA 562 (LINC00562) is a long non-coding RNA (lncRNA), a type of RNA molecule longer than 200 nucleotides that does not encode a protein[7][1][3]. LINC00562 is overexpressed in gastric cancer tissues and cell lines, where it acts as an oncogenic regulator by promoting cell proliferation and migration and inhibiting apoptosis[2]. Mechanistically, it functions as a competing endogenous RNA that binds to and sequesters miR-4636, thereby activating downstream targets such as AP1S3, which are involved in malignant cell behaviors[2]. Its role is being investigated as a biomarker and possible therapeutic target in cancer research, but there are no drugs directly targeting LINC00562 in clinical use and it is not a conventional therapeutic target type such as a receptor, enzyme, or transporter[2][1].
- Other names
- LINC00562
02
Biological functions
Regulation of gene expressionRegulation of cell proliferationRegulation of apoptosisRegulation of cell migrationCompeting endogenous RNA activity (ceRNA)
03
Disease associations
Cancer (notably gastric cancer)
04
Biomarkers
Potential biomarker for gastric cancer prognosis or progression (research context, not clinical standard) [2]
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