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Target intelligence / Profile preview
Long intergenic non-protein coding RNA 582 (LINC00582)
- Target
- LINC00582
- Molecular classification
- Long non-coding RNA (lncRNA), Other (non-protein coding gene)
01
Overview
Long intergenic non-protein coding RNA 582 (LINC00582, also called SMILO) is a human long non-coding RNA gene located on chromosome 1. It is specifically transcribed as a non-protein-coding RNA and plays a role in regulating gene expression and epigenetic processes. Its differential expression has been associated with cancer progression and inflammation, with emerging importance in multiple myeloma prognosis. Although it is functionally relevant in disease contexts, LINC00582 is not a conventional therapeutic target and is not directly addressed by any approved drugs or small molecules.
- Other names
- SMILO (Specific Myeloma Intergenic Long Non-coding RNA)
02
Biological functions
Regulation of gene expressionEpigenetic regulationPossible involvement in inflammatory responsesMay serve prognostic functions in cancer models, notably multiple myeloma
03
Disease associations
Cancer (expression implicated in tumor biology and prognosis, particularly multiple myeloma)Inflammation (differential expression in inflammatory cell models)
04
Biomarkers
Potential prognostic biomarker in cancer (included in lncRNA models for outcomes in multiple myeloma and possibly other tumors)
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