Long intergenic non-protein coding RNA 606 (LINC00606)

Long intergenic non-protein coding RNA 606 (LINC00606) is a human long non-coding RNA (lncRNA), specifically a long intergenic non-coding RNA (lincRNA) that does not overlap protein-coding genes. LINC00606 is highly expressed in some tumor types, notably glioblastoma, where it drives cell proliferation and migration, and suppresses apoptosis. Functionally, it regulates gene networks through sponging microRNAs (e.g., miR-486-3p), modulating the expression of genes like TCF12, and interacting with the protein ATP11B to impact signaling pathways including PI3K/AKT. Its high expression is associated with poor prognosis in glioma, suggesting its utility as a biomarker. No approved drugs directly target LINC00606, and therapeutic targeting is an emerging research area rather than established clinical reality.

Other names

LINC00606Long intergenic non-protein coding RNA 606

Acts as a competing endogenous RNA ("molecular sponge") for microRNAs such as miR-486-3p, thereby regulating the expression of downstream genes (e.g., TCF12); Binds to proteins (e.g., ATP11B) and modulates the PI3K/AKT signaling pathway