Long intergenic non-protein coding RNA 621 (LINC00621)

Long intergenic non-protein coding RNA 621 (LINC00621) is a human lncRNA gene found on chromosome 13q12.12[15]. It encodes a long non-coding RNA molecule variably expressed in normal and tumor tissues, notably upregulated in lung adenocarcinoma and associated with poor clinical outcomes[2]. LINC00621 acts mechanistically as a molecular sponge for miR-34a-5p, resulting in the upregulation of TGFBR1 and increased activation of the TGF-β signaling pathway, promoting tumorigenesis and metastasis[2]. Its expression is transcriptionally upregulated by FOXA1, a transcription factor involved in chromatin remodeling. LINC00621 is being actively investigated as a biomarker for cancer prognosis and as a potential therapeutic target[2][5][6][15].

Other names

LINC00621NCBI Gene: 100996930Ensembl: ENSG00000262619

As of current data, drugs would be expected to modulate LINC00621 expression or function, likely through antisense oligonucleotides, RNA interference, or small molecules influencing its transcriptional regulation or miRNA sponging activity[2].