Long intergenic non-protein coding RNA 632 (LINC00632)

Long intergenic non-protein coding RNA 632 (LINC00632) is a long non-coding RNA (>200 nucleotides) that does not encode a protein but plays regulatory roles in gene expression, particularly modulating microRNA activity and circular RNA (such as ciRS-7) biogenesis. LINC00632 is implicated in immune regulation—specifically in the differentiation of CD4+ T cells and the Th1/Th2 balance central to allergic rhinitis, where its upregulation is associated with improved symptoms and treatment response[2][4][5]. In cancer, notably non-small cell lung cancer, LINC00632 acts as a tumor suppressor: reduced expression is associated with metastasis and poor prognosis, while its overexpression inhibits tumor growth, partly through the competitive inhibition of oncogenic microRNAs such as miR-1203[6]. LINC00632 and related lincRNAs do not fit into classic "target" classes such as receptors or enzymes but can serve as biomarkers and potential future drug targets for RNA-based therapies[1][2][6].

Other names

ASINCARSTCDR1NATciRS-7CDR1asMDHDHALDOA related specific transcriptmalate dehydrogenase degradation helperBMORCDR1-ASbrain metastasis oncogenic lncRNA

Acts as a molecular sponge for microRNAs (e.g., miR-1203), thus modulating their activity