Long intergenic non-protein coding RNA 641 (LINC00641)

Long intergenic non-protein coding RNA 641 (LINC00641) is a long non-coding RNA (lncRNA) that does not encode a protein but regulates gene expression primarily through RNA-based mechanisms, such as sponging microRNAs (miRNAs) and modulating the expression of tumor-related genes[1][3][5][10]. Depending on cellular context and tumor type, LINC00641 can act as a tumor suppressor (as in bladder cancer, non-small cell lung cancer, ovarian cancer, glioma, cutaneous squamous cell carcinoma) or as an oncogene (as reported in leukemia, gastric cancer, rectal and renal cancers)[2][3][5][8][10]. Experimental manipulation of LINC00641 alters cell proliferation, apoptosis, invasion, migration, and drug resistance via several molecular axes, with notable involvement in ceRNA networks with miRNAs. It is being studied as a prognostic biomarker and a potential therapeutic target, especially in cancers where its deregulation contributes to disease progression or drug resistance[2][5][6][10].

Other names

LINC00641long intergenic non-protein coding RNA 641

Acts as a tumor suppressor or oncogene depending on cancer type by sponging oncogenic or tumor-suppressive miRNAs (e.g., miR-197-3p, miR-320a, miR-424-5p, miR-582-5p) and thereby regulating downstream tumor-related genes such as KLF10, PLSCR4, and others