Long intergenic non-protein coding RNA 663 (LINC00663)

Long intergenic non-protein coding RNA 663 (LINC00663) is a human long non-coding RNA gene that does not encode a protein product. It is primarily localized in the nucleus and functions as a gene regulator, partly through interacting with transcription factors such as EBF1 to upregulate other genes like NR2F1. LINC00663 is overexpressed in various cancers, including bladder, pancreatic, and glioma, where it fosters cell proliferation, inflammation, and angiogenesis. Loss of LINC00663 suppresses tumor growth and inflammatory signaling in preclinical studies. While not a classical therapeutic target, it is of increasing interest for its roles in oncogenesis and as a potential cancer biomarker.

Other names

MGC39821lincRNA-663Long intergenic non-protein coding RNA 663

Not applicable for drugs, as there are no known drugs targeting this lncRNA. Mechanistically, LINC00663 acts by scaffolding transcription factors (e.g., EBF1) to gene promoters (e.g., NR2F1), thereby regulating the expression of downstream genes involved in cancer development and inflammation.