Long intergenic non-protein coding RNA 665 (LINC00665)

Long intergenic non-protein coding RNA 665 (LINC00665) is a lncRNA that regulates tumor cell behaviors such as proliferation, invasion, migration, angiogenesis, apoptosis, and metabolism across various cancer types. LINC00665 acts as a molecular sponge for ~25 miRNAs and directly influences the expression/stability of ten protein-coding genes. Remarkably, LINC00665 encodes a biologically active micropeptide, CIP2A-BP (CIP2A binding peptide), which binds the oncogene CIP2A to perturb the PP2A complex and inhibit cancer cell invasion and metastasis via key oncogenic signaling pathways (PI3K/AKT/NF-κB, Wnt/β-catenin, etc.). LINC00665 is dysregulated in numerous cancers, where its expression correlates with disease progression, poor prognosis, and resistance to chemotherapy. Its unique coding ability and regulatory functions make it a promising biomarker and candidate for targeted cancer therapeutics but its role remains preclinical as of the current literature.

Other names

LINC00665CIP2A-BPCIP2A binding peptide

Drugs may modulate LINC00665 or be affected by its expression; e.g. Cisplatin/gemcitabine resistance is regulated by LINC00665 via EMT, stemness, and ceRNA-mediated gene expression. CIP2A-BP binds CIP2A, affects PP2A complex, thus impacting PI3K/AKT/NF-κB signaling.