Long intergenic non-protein coding RNA 670 (LINC00670)

Long intergenic non-protein coding RNA 670 (LINC00670), also known as CARDINAL, is a cardiac-specific long non-coding RNA located upstream of the myocardin (MYOCD) gene on chromosome 17. Approximately 2.8 kb in length and comprised of four exons, LINC00670 is notable for its enrichment in heart tissue and conservation in mice[4][1]. It acts through multiple mechanisms: in the nucleus, it interacts with the transcription factor serum response factor (SRF) to antagonize mitogenic gene transcription, while in the cytoplasm, it associates with ribosomes to modulate protein translation[1][4]. LINC00670 plays a critical role in attenuating cardiac hypertrophy and balancing cardiac gene expression, and its dysregulation exacerbates systolic dysfunction following myocardial infarction[4][1]. Recent studies indicate that LINC00670 (CARDINAL) may also serve as a potential biomarker and therapeutic target in certain cancers, such as gastric cancer[3], highlighting its emerging significance in both cardiovascular disease and oncology.

Other names

CARDINALFLJ34690cardiac lncRNA transcribed adjacent to myocardin

Regulation of cardiac hypertrophy through modulation of ribosome association and interaction with serum response factor (SRF); influences severity of heart failure and cardiac hypertrophy; possible roles in cancer cell regulation