Long intergenic non-protein coding RNA 674 (LINC00674)

Long intergenic non-protein coding RNA 674 (LINC00674), also known as CALA (cytoplasmic G3BP1-associated lncRNA), is a spliced multi-exonic long non-coding RNA gene located on human chromosome 17q24.2. It does not encode a protein but plays a key role as a cytoplasmic regulator of gene expression, primarily by scaffolding ribonucleoprotein complexes involving G3BP1, G3BP2, UPF1, and associated NMD factors[2][13]. CALA modulates RNA turnover rates and the efficiency of nonsense-mediated mRNA decay in endothelial cells, thereby affecting cellular homeostasis, migration, and stress responses[2][4][6][10]. Although not a conventional drug target, its biological functions are implicated in endothelial physiology and cancer, making it a subject of ongoing molecular research. There are no known drugs directly interacting with LINC00674, and its clinical therapeutic utility remains unexplored[2][11][13].

Other names

LINC00674CALA (cytoplasmic G3BP1-associated lncRNA)

Not applicable. No approved or investigational drugs have a defined mechanism of action involving LINC00674