Long intergenic non-protein coding RNA 680 (LINC00680)

Long intergenic non-protein coding RNA 680 (LINC00680) is a human long non-coding RNA located on chromosome 6 (HGNC:44417), characterized by its lack of protein-coding potential[5][9]. It acts primarily as a competing endogenous RNA (ceRNA), regulating the activity of several microRNAs including miR-320a and miR-320b, thus modulating the expression of key genes involved in cell proliferation, apoptosis, and immune responses (e.g., MAPK1 and EGR3)[2][4][6]. Elevated levels of LINC00680 are associated with increased disease severity in myasthenia gravis and are implicated in tumor progression in cancers such as glioblastoma and esophageal squamous cell carcinoma. These properties make LINC00680 both a potential diagnostic biomarker and a therapeutic target in multiple disease contexts[2][4][6].

Other names

LINC00680

MicroRNA sponging (e.g., sponges miR-320a and miR-320b, affecting downstream targets such as MAPK1, EGR3, and PAK6); CeRNA network regulation