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Long intergenic non-protein coding RNA 698 (LINC00698)
- Target
- LINC00698
- Molecular classification
- Long non-coding RNA (lncRNA), Other (specifically non-coding RNA family)
01
Overview
Long intergenic non-protein coding RNA 698 (LINC00698) is a long non-coding RNA gene located on chromosome 3. It does not encode a protein and instead functions as a regulatory RNA molecule. LINC00698 is upregulated in melanoma stem cells, where it promotes tumorigenicity by supporting cell proliferation, inhibiting apoptosis, and maintaining stemness. Mechanistically, LINC00698 exerts its effects through two main actions: (1) acting as a molecular "sponge" for miR-3132, thereby upregulating the pro-tumorigenic transcription factor TCF7, and (2) binding directly to the protein hnRNPM, stabilizing it and promoting cancer cell survival and stem cell-like properties. While LINC00698 is not a classical therapeutic receptor or drug target, it is emerging as a potential biomarker and regulatory node in tumor biology, particularly in melanoma[2][3][1].
- Other names
- RP11-129K20.2
02
Biological functions
Regulation of apoptosisRegulation of cell cycleRegulation of cell proliferationPromotion of stemness in cancer stem cellsModulation of gene expression via miRNA sponge function (specifically sponging miR-3132 to regulate TCF7)Protein interaction/regulation (modulates stability of hnRNPM protein)Other (lncRNA-mediated post-transcriptional and protein regulatory functions)
03
Disease associations
Cancer (specifically melanoma progression and stemness of melanoma stem cells)Other cancers possible (as lncRNA dysregulation is common in tumors), but direct evidence is currently limited
04
Safety considerations
Potential concern: Knockdown or inhibition could affect normal stem cell populations or cell cycle regulation, but specific therapeutic safety data are lacking
05
Biomarkers
Expression of LINC00698 in tumors as a prognostic or diagnostic biomarker for melanoma stemness, cell proliferation, and apoptosisKi67 expression (used as readout in LINC00698-silenced tumors for proliferation monitoring in research)
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