Long intergenic non-protein coding RNA 703 (LINC00703)

Long intergenic non-protein coding RNA 703 (LINC00703) is a long non-coding RNA gene located on chromosome 10 (10p15.1), classified as an lncRNA without protein-coding capacity[1][5][11][13]. It functions as a tumor suppressor in several cancers, particularly gastric cancer and non-small cell lung cancer, through its ability to regulate gene expression post-transcriptionally. LINC00703 acts as a competing endogenous RNA (ceRNA) for miR-181a, thereby increasing the expression of the tumor suppressor KLF6, inhibiting cell proliferation, migration, invasion, and promoting apoptosis[2][4]. Its downregulation is associated with tumorigenesis, while overexpression suppresses tumor cell growth, indicating potential utility as both a diagnostic/prognostic biomarker and a therapeutic target in oncology. No drugs targeting LINC00703 are currently reported in humans, but its roles as a ceRNA and regulator of key cell cycle and apoptosis genes make it a subject of ongoing research[2][4][13].

Other names

LINC00703

Modulates expression of specific mRNAs by acting as a molecular sponge for microRNAs (e.g., sequestering miR-181a, leading to derepression/upregulation of KLF6 tumor suppressor gene)[2][4]; Alters cell cycle regulators (e.g., downregulates cyclin D1 and CDK4 in non-small cell lung cancer)[4]