Long intergenic non-protein coding RNA 858 (LINC00858)

Long intergenic non-protein coding RNA 858 (LINC00858) is a long non-coding RNA molecule, approximately 2685 nucleotides in length, located at 10q23.1. LINC00858 exhibits abnormally high expression in a wide range of human cancers, notably colorectal cancer and non-small cell lung cancer, where it is associated with tumor progression, poor prognosis, and increased metastatic potential. Mechanistically, LINC00858 acts as a competitive endogenous RNA (ceRNA), sponging various microRNAs such as miR-25-3p, miR-22-3p, miR-3182, and miR-422a, thereby modulating downstream gene targets including SMAD7, YWHAZ, KLK4, and CDK14. In colon cancer, LINC00858 recruits the transcription factor RAD21 to the promoter of the PCNP gene, activating the STAT3/5 pathway. Its dysregulation promotes cell proliferation, migration, invasion, suppression of apoptosis, and is tied to clinical features of tumor aggressiveness and advanced stage. LINC00858 is regarded as a novel oncogenic lncRNA and emerging therapeutic target, although no current drugs directly target this molecule. Detection of LINC00858 expression is increasingly recognized as a valuable biomarker for identifying high-risk cancer patients and monitoring disease progression.

Other names

LINC00858CRCAL-2LNMAT2Colorectal cancer associated lncRNALymph node metastasis-associated transcript 2

Competitive endogenous RNA sponge for microRNAs (e.g., miR-25-3p, miR-22-3p, miR-3182, miR-422a, miR-139). Modulation of gene expression (e.g., upregulates proteins like SMAD7, KLK4, YWHAZ, CDK14, PCNP, through microRNA regulation). Recruitment of transcription factors (e.g., RAD21 to PCNP promoter). Impacts signaling pathways (e.g., MAPK, TGF-β, STAT3/5).