Long intergenic non-protein coding RNA 870 (LINC00870)

Long intergenic non-protein coding RNA 870 (LINC00870) is a human long non-coding RNA, specifically classified as a long intergenic non-coding RNA (lincRNA). LINC00870 is longer than 200 nucleotides, lacks protein-coding potential, and is transcribed from regions devoid of overlapping protein-coding genes. LINC00870 has been shown to be upregulated in peripheral blood mononuclear cells during Mycobacterium tuberculosis infection, where it modulates the Th1/Th2 immune balance by activating the JAK/STAT signaling pathway. Its levels are increased in sputum and plasma from active tuberculosis and latent tuberculosis patients, and decrease after anti-tuberculosis therapy, supporting its role as a biomarker for disease diagnosis and treatment response. No drugs directly targeting LINC00870 are currently reported, and its safety profile as a therapeutic target remains undetermined. Broader evidence suggests that lincRNAs like LINC00870 participate in diverse aspects of gene regulation, including transcriptional and post-transcriptional control, and some may be implicated in diseases such as cancer.

Other names

LINC00870