Long intergenic non-protein coding RNA 887 (LINC00887)

LINC00887 is a long non-coding RNA (lncRNA) expressed in human cells, found to promote cell proliferation, migration, and metastasis in various cancers, including colorectal, lung, renal cell carcinoma, glioma, and papillary thyroid cancer[1][2][5][6]. It can function as a competing endogenous RNA, regulating miRNA degradation and acting through epigenetic modification pathways, such as GCN5-dependent H3K27 crotonylation and editing of ETS1 transcription[2]. Additionally, LINC00887 encodes a micropeptide (ACLY-BP) which stabilizes ATP citrate lyase (ACLY), thus promoting lipid deposition and providing acetyl-CoA for cellular metabolism[6]. It is upregulated in tumor tissue and associated with poor prognosis, cancer cell migration, and metastasis potential. LINC00887 and its functional protein product (ACLY-BP) are under investigation as biomarkers and therapeutic targets in cancer research[1][2][5][6].

Other names

ACLY-BPHEIRCCLINC02036linc-ATP13A4-8high-expressed in renal cell carcinomaACLY binding proteinLINC00887long intergenic non-protein coding RNA 2036

For therapeutic inhibition, likely action via RNA interference (siRNA, shRNA) targeting LINC00887 transcript or micropeptide inhibition[1][2][6].