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Long intergenic non-protein coding RNA 905 (LINC00905)
- Target
- LINC00905
- Molecular classification
- Long intergenic non-coding RNA (lincRNA), Non-coding RNA, Other
01
Overview
Long intergenic non-protein coding RNA 905 (LINC00905) is a human long intergenic non-coding RNA gene. lincRNAs are RNA transcripts longer than 200 nucleotides that do not code for proteins and do not overlap protein-coding genes. They are a subtype of long non-coding RNAs (lncRNAs) with emerging regulatory roles in cell biology, including chromatin remodeling, transcriptional regulation, RNA stability, and modulation of gene expression, both in cis (regulating nearby genes) and trans (regulating distant genes). While many lincRNAs are not yet well characterized, some—including LINC00905—have been implicated in disease models, especially cancer biology where they may serve as prognostic markers or contribute to disease mechanisms. However, LINC00905 is not established as a therapeutic target, and its direct functional characterization remains limited in current databases and literature.
- Other names
- FLJ25328LINC01855Long intergenic non-protein coding RNA 1855CTD-2231E14.4LINC00905
02
Mechanism of action
Not applicable; no drugs have a defined mechanism of action via this lincRNA.
03
Biological functions
Regulation of gene expressionChromatin remodelingGenome architectureRNA stabilizationTranscription regulation (including enhancer-like activity)Other
04
Disease associations
Cancer (association reported, but functional details vary by context; for example, endometrial cancer recurrence)Other (several lincRNAs implicated generally in complex human diseases, but LINC00905's specific roles are not well established)
05
Biomarkers
LINC00905 as a candidate molecular biomarker in cancer risk stratification or recurrence models (e.g., endometrial cancer)
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