Long intergenic non-protein coding RNA 907 (LINC00907)

Long intergenic non-protein coding RNA 907 (LINC00907) is a long non-coding RNA (lncRNA) that does not encode a protein but participates in the post-transcriptional regulation of gene expression. LINC00907 is significantly upregulated in liver tissues from patients and mouse models with non-alcoholic steatohepatitis (NASH) and non-alcoholic fatty liver disease (NAFLD)[5][3][2]. Its pathogenic function is mediated through a competitive endogenous RNA (ceRNA) mechanism: LINC00907 binds and sequesters miRNA-942-5p, reducing the microRNA’s availability to repress its downstream target, TAO kinase 1 (TAOK1). This relief of TAOK1 from miRNA-mediated repression leads to increased TAOK1 expression, which in turn enhances hepatic lipid accumulation, alters lipid metabolism–related gene expression, modulates immune pathways, and reduces apoptosis in hepatocytes. LINC00907’s activity in promoting these effects drives progression from NAFLD to NASH, and inhibition of LINC00907 or modulation of the associated axis has been proposed as a potential therapeutic strategy for NASH[5][3][2][4]. No direct drug interactions are currently documented, and its full clinical utility as a biomarker or therapeutic target requires further investigation.

Other names

LINC00907lincRNA00907

Competitive endogenous RNA (ceRNA) that sequesters miRNA-942-5p, leading to derepression of TAOK1 and promoting lipid accumulation in hepatocytes