Long intergenic non-protein coding RNA 917 (LINC00917)

LINC00917 (long intergenic non-protein coding RNA 917) is a long non-coding RNA gene located on chromosome 16q24, defined by its lack of protein-coding potential and its position between protein-coding genes[1][5]. LINC00917 participates in gene regulatory networks, exerting its functions by acting as a competing endogenous RNA (miRNA sponge), particularly for miR-149-5p, which impacts the regulation of targets such as NLRP1 involved in inflammation and pyroptosis[2][3]. Its dysregulation has been linked to intervertebral disc degeneration, where it is upregulated and promotes pathological processes such as reduced cell proliferation and increased inflammatory cell death in nucleus pulposus cells[2][3]. Additionally, elevated levels of exosomal LINC00917 in serum have been associated with non-small cell lung cancer, correlating with advanced disease stage and worse prognosis, suggesting a potential role as a non-invasive biomarker[4][6]. No current evidence supports its direct targeting by therapeutic drugs.

Other names

LINC00917Long intergenic non-protein coding RNA 917

Not applicable. As an lncRNA, LINC00917 does not have mechanisms of action analogous to proteins; its influence is mediated through *RNA-RNA interactions* and regulation of microRNAs (notably acting as a sponge for miR-149-5p, thereby modulating the expression of targets such as NLRP1)