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Long intergenic non-protein coding RNA 923 (LINC00923)
- Target
- LINC00923
- Molecular classification
- Long non-coding RNA, Non-coding RNA, Other
01
Overview
Long intergenic non-protein coding RNA 923 (LINC00923) is a long non-coding RNA (lncRNA) transcript located on human chromosome 15q26[3][5]. It does not encode a protein but is transcribed as RNA and is predominantly localized to the nucleus in human cells[2]. LINC00923 has been identified as a gene with prognostic implications in cancer, particularly lung squamous cell carcinoma, where its expression is associated with cell proliferation, invasion, and migration, as demonstrated in cell-based assays[2]. Additionally, genetic variants in LINC00923 have been linked to susceptibility and outcomes in chronic kidney disease and related kidney function traits in several large-scale genetic studies[4]. Currently, there are no known drugs or direct therapeutic agents that specifically target LINC00923, and it is not considered a traditional therapeutic target such as a receptor, enzyme, transporter, or signaling molecule but serves as a molecular biomarker in research and clinical genomics contexts[1][2][4][5].
- Other names
- LINC02254LOC101927310Long intergenic non-protein coding RNA 2254
02
Biological functions
Potential regulation of cell proliferationregulation of cell invasionregulation of cell migration
03
Disease associations
Cancer (prognostic marker in lung squamous cell carcinoma)Kidney disease/Chronic Kidney Disease (CKD)
04
Biomarkers
Prognosis marker for lung squamous cell carcinoma (LUSC)genetic variants associated with chronic kidney disease
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