long intergenic non-protein coding RNA 926 (LINC00926)

Long intergenic non-protein coding RNA 926 (LINC00926) is a human lncRNA involved in transcriptional regulation, epigenetic modification, and cellular phenotype control. It acts as a tumor suppressor in breast cancer by enhancing ubiquitination and degradation of glycolytic enzymes (e.g., PGK1), thus modulating metabolic reprogramming associated with cancer progression. It participates in immune and inflammatory responses via recruitment of histone methyltransferases such as MLL1 to promote H3K4 trimethylation at target gene promoters, enhancing the transcription of key inflammatory genes (e.g., WNT10B, IFNG, IL17A). LINC00926 may also have a role in vascular responses to hypoxia and in hematological malignancies such as Hodgkin lymphoma, acting as a protective biomarker in specific contexts. Key literature demonstrates LINC00926’s role in gene regulation and disease context, but not as a druggable therapeutic target nor as a classic receptor, enzyme, or transporter.

Other names

LINC00926linc00926