Long intergenic non-protein coding RNA 943 (LINC00943)

Long intergenic non-protein coding RNA 943 (LINC00943) is a long non-coding RNA (lncRNA) located on chromosome 12[1][3]. LINC00943 does not encode a protein but modulates various cellular processes, including cell proliferation, differentiation, apoptosis, and gene expression regulation, likely through interaction with proteins or other RNAs[1][2][4]. It is implicated in the pathology of various cancers—such as lung, breast, and colorectal cancer—where its expression levels often correlate with tumor progression and patient prognosis[1][2][4]. Specifically, in lung squamous cell carcinoma, LINC00943 acts as a molecular sponge for miR-196b-5p, and its overexpression suppresses tumor cell migration and invasion, positioning it as a promising prognostic biomarker and putative therapeutic target for this malignancy[2][4]. LINC00943 has also been implicated in other disease states, such as Parkinson’s disease, underlining its broad functional significance. There are currently no known direct drug interactions or safety concerns reported for this molecular entity.

Other names

LINC00943

Acts as a molecular sponge for microRNAs (e.g., miR-196b-5p), modulating their bioavailability and thereby controlling the post-transcriptional regulation of target genes[2][4].