Long intergenic non-protein coding RNA 945 (LINC00945)

Long intergenic non-protein coding RNA 945 (LINC00945) is a human long intergenic non-coding RNA (lincRNA) that does not encode protein but regulates gene expression at multiple levels, particularly through epigenetic and chromatin-associated mechanisms. It is identified as a super-enhancer-associated lncRNA (SE-lncRNA) in glioma, where it is highly upregulated compared to normal brain tissue. Elevated LINC00945 expression promotes tumor cell proliferation, epithelial-mesenchymal transition, migration, invasion, and in vivo tumor growth, contributing to glioma pathogenesis and poor prognosis. Mechanistically, its expression is regulated by super-enhancers involving cofactors such as BRD4 and MED1, which are key chromatin regulators implicated in cancer. LINC00945 is under study as a prognostic biomarker and is considered a novel candidate therapeutic target in glioma research. Its biological functions, however, are not limited to cancer and may extend to the fine-tuning of gene expression across various tissues, typical of lincRNAs [1][2][5].

Other names

LINC00945TCONS_00028834ENSG00000232539 (Ensembl)101930746 (NCBI Gene)

Not established; inferred mechanisms would involve epigenetic regulation or modulation of transcriptional networks due to its effect on chromatin structure and gene transcription