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Target intelligence / Profile preview
Long intergenic non-protein coding RNA 951 (LINC00951)
- Target
- LINC00951
- Molecular classification
- Long non-coding RNA, lincRNA
01
Overview
Long intergenic non-protein coding RNA 951 (LINC00951) is a long non-coding RNA gene found at human chromosome 6p21.2 that does not encode a protein but may regulate gene expression at multiple levels. It is studied primarily for its involvement in cancer through single-nucleotide polymorphisms (e.g., rs11752942) that can be associated with susceptibility to various malignancies, including esophageal cancer and head and neck cancer. While SNPs within LINC00951 may influence cancer risk in certain populations, direct evidence of functional involvement is limited, and its use as a therapeutic target or clinical biomarker remains investigational.
- Other names
- lincRNA-uc003opf.1FLJ41649LINC00951
02
Biological functions
Regulation of gene expressionputative role in cell-cycle controlpossible modulator in cancer biology
03
Disease associations
Cancer (notably esophageal cancer, esophagogastric junction carcinoma, head and neck cancers through SNP association studies, though direct functional disease implication is not strongly established and may vary by population)
04
Biomarkers
Potential biomarker status for cancer SNP risk (rs11752942 A>G variant studied in risk association for esophageal and head/neck cancers, but utility remains experimental and population-dependent)
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