Long intergenic non-protein coding RNA 958 (LINC00958)

LINC00958 (Long intergenic non-protein coding RNA 958) is an lncRNA molecule encoded on human chromosome 11. It does not translate into a protein but operates as a regulatory RNA controlling the expression of multiple genes involved in cancer progression. LINC00958 interacts with chromatin, histones, and miRNAs, influencing both transcriptional and post-transcriptional mechanisms. It is highly upregulated in a diverse set of malignancies and promotes tumor proliferation, invasiveness, resistance to chemotherapy/radiotherapy, and inhibition of apoptosis. Its expression serves as a biomarker for diagnosis, prognosis, and therapeutic guidance, especially in cancers like lung adenocarcinoma and B-cell acute lymphoblastic leukaemia. Experimental silencing of LINC00958 reduces cancer cell proliferation and invasiveness, supporting its candidacy as a therapeutic target for future nucleic acid-based therapies.

Other names

BLACAT2CTC-497E21.4

Most mechanisms described involve RNA interference/silencing; potential future drug approaches would likely aim to inhibit LINC00958 expression or disrupt its interactions with chromatin/histones/miRNAs. Functions as a competing endogenous RNA (ceRNA), sponging miRNAs and modulating gene networks involved in proliferation and apoptosis.