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Long intergenic non-protein coding RNA 959 (LINC00959)
- Target
- LINC00959
- Molecular classification
- Long non-coding RNA (lncRNA), Long intergenic non-protein coding RNA (lincRNA)
01
Overview
Long intergenic non-protein coding RNA 959 (LINC00959; also known as C10orf143) is a long non-coding RNA highly expressed in malignancies such as breast cancer and lung squamous cell carcinoma[1][2]. High levels of LINC00959 are associated with poor prognosis in breast cancer and may help predict disease recurrence and therapeutic response, particularly to endocrine therapy in hormone receptor-positive cases[2][5]. It is viewed as a promising biomarker and potential secondary therapeutic target, though its mechanisms remain under investigation. No specific drugs or molecular therapies currently target C10orf143/LINC00959 directly[2][3][4][1].
- Other names
- C10orf143Chromosome 10 open reading frame 143LINC00959Uncharacterized protein C10orf143Long intergenic non-protein coding RNA 959
02
Biological functions
Regulation of gene expression (by RNA mechanism)Potentially modulates cell proliferation, invasion, and migration in cancerMay act as a biomarker for malignancy and prognosis
03
Disease associations
Cancer (breast cancer, colorectal cancer, non-small cell lung carcinoma, lung squamous cell carcinoma)Possible association with hypotonia, ataxia, and delayed development syndrome
04
Biomarkers
High expression level as a prognostic marker for breast cancer and lung squamous cell carcinoma malignancy
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