Long intergenic non-protein coding RNA 972 (LINC00972)

Long intergenic non-protein coding RNA 972 (LINC00972), also known as PLADE or Platinum sensitivity-related LncRNA, is a long non-coding RNA classified as an intergenic lncRNA located on chromosome 7[1][5][7]. LINC00972 has been implicated in the regulation of cell proliferation, migration, invasion, and apoptosis, particularly in the context of high-grade serous ovarian cancer (HGSOC). Expression of LINC00972/PLADE is reduced in platinum-resistant ovarian cancer tissue and exosomes, while higher expression predicts better progression-free survival. Mechanistic studies show LINC00972 promotes platinum sensitivity by downregulating the RNA-binding protein HNRNPD, inducing R-loop formation, and enhancing DNA damage, which sensitizes tumors to cisplatin-based chemotherapy[2]. Clinical and multi-omic data suggest LINC00972 may serve as a useful biomarker for predicting response to platinum-based chemotherapy, though it is not currently a direct therapeutic target.

Other names

LINC00972PLADEPlatinum sensitivity-related LncRNAPlatinum sensitivity-related lncRNA (PLADE)

Modulates chemotherapy response by binding to and downregulating HNRNPD (via VHL-mediated ubiquitination), increasing RNA:DNA hybrids (R-loop) and DNA damage, leading to enhanced sensitivity to platinum drugs in cancer cells[2].