Long intergenic noncoding RNA regulator of interleukin-2 receptor alpha (LIRIL2R)

LIRIL2R (long intergenic noncoding RNA regulator of interleukin-2 receptor alpha) is a long noncoding RNA identified at the chromosome 6p25.3 locus and highly upregulated during early human regulatory T cell (Treg) differentiation[1][5]. It functions as a nuclear RNA that binds upstream of the IL2RA (CD25) gene, shaping its epigenetic landscape and regulating its transcription. LIRIL2R deficiency leads to reduced IL2RA and FOXP3 expression, loss of Treg signature and suppressive phenotype, and increased expression of effector T cell-associated genes. As such, LIRIL2R is a key epigenetic regulator of Treg development and immune homeostasis, highlighting its potential importance in diseases characterized by Treg dysfunction such as autoimmunity and cancer. However, LIRIL2R itself is not a conventional therapeutic target such as a receptor or enzyme and no drugs have been reported to target it directly[1][3][5].

Other names

LIRIL2RlincRNA regulator of IL2RALong intergenic noncoding RNA regulator of IL2RA

Not applicable; no drugs known to target this molecule