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Long Non-coding RNA (lncRNA)

Target: lncRNA
Molecular classification: RNA, Non-coding RNA

Overview

Long non-coding RNAs (lncRNAs) are a diverse class of RNA molecules, typically longer than 200 nucleotides, that do not code for proteins. They regulate gene expression at multiple levels, including epigenetic, transcriptional, and post-transcriptional regulation. LncRNAs function as scaffolds, guides, decoys, or signals, influencing chromatin remodeling, transcription, RNA processing, and translation. They play critical roles in development, cell differentiation, and disease, particularly cancer.

Other names: Long ncRNAlnc ncRNA

Mechanism of action

Modulation of gene expression through epigenetic, transcriptional, and post-transcriptional mechanisms.

Biological functions

Gene expression controlChromatin remodelingTranscriptional regulationPost-transcriptional regulationDevelopmentCell differentiationCell cycle controlmRNA stabilitySplicingTransportTranslation

Disease associations

CancerDevelopmental disordersOther diseases (unspecified)

Safety considerations

Off-target effects due to low sequence conservationDelivery challenges for RNA-based therapeuticsPotential for unintended consequences on gene regulation

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