Long non-coding RNA–protein interaction

Long non-coding RNA–protein interactions describe the physical bindings between long non-coding RNAs (typically >200 nucleotides and not coding for protein) and RNA-binding proteins (RBPs). These interactions are central to many cellular processes, including gene expression regulation at the transcriptional and post-transcriptional levels, chromatin remodeling, mRNA splicing, epigenetic modification, and cellular response to stimuli. lncRNA–protein interactions are highly specific in many cases but form a vast and largely uncharacterized network across cell types and pathologies. Dysregulation of these interactions is implicated in diseases such as cancer, neurodegeneration, and immune disorders[1][2][3][4][5][6][7][8]. This term refers to a mechanistic class and not an individual target suitable for therapeutic intervention except in cases where a specific lncRNA–protein pair is identified as a disease driver. Note: This is not a single molecular target, but a class of macromolecular interactions. Use of this term as a “target” is non-specific and does not reflect a discrete, actionable drug target[2][3][5][6][7].

Other names

lncRNA–RBP interactionlncRNA–protein complexlncRNA–protein binding

Blocking or mimicking specific lncRNA–protein binding. Modulating lncRNA stability or expression (if targeting a specific pair; not for the class as a whole).