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Long non-coding RNA BX111 (BX111)
- Target
- BX111
- Molecular classification
- Long non-coding RNA (lncRNA), Transcriptional regulator (via modulation of transcription factors)
01
Overview
Long non-coding RNA BX111 is a hypoxia-inducible lncRNA overexpressed in pancreatic cancer tissues, where it promotes tumor growth, invasion, and metastasis by activating transcription of the EMT regulator ZEB1. BX111 acts by recruiting the transcription factor Y-box protein 1 (YB1) to the ZEB1 promoter, driving ZEB1 upregulation and downstream EMT targets such as E-cadherin and MMP2. Its transcription is induced by hypoxia (via HIF-1α), linking tumor microenvironmental stress to aggressive cancer behavior. High BX111 levels correlate with poor patient outcomes, making it both a candidate biomarker and a potential therapeutic target in oncology.
- Other names
- LncRNA-BX111BX111hypoxia-induced lncRNA BX111
02
Mechanism of action
Regulates gene transcription by recruiting Y-box protein 1 (YB1) to the ZEB1 promoter, enhancing ZEB1 expression and promoting EMT in cancer cells. Mediates hypoxia-induced EMT via HIF-1α induction of BX111 transcription, establishing a link between tumor hypoxia and metastasis.
03
Biological functions
Regulation of transcription (activates ZEB1 transcription)Promotion of epithelial-mesenchymal transition (EMT)Cell proliferationCell migration and invasionResponse to hypoxia (mediated by HIF-1α)
04
Disease associations
Cancerpancreatic cancer
05
Safety considerations
Targeting lncRNAs like BX111 may impact normal physiological pathways related to EMT and tissue regenerationOff-target effects common in oligonucleotide or RNA-based therapeutics
06
Biomarkers
BX111 expression level in tumor tissue
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