Long non-coding RNA ENSG00000279204 (ENSG00000279204)

ENSG00000279204 encodes a long non-coding RNA that acts as a competing endogenous RNA in breast cancer, particularly by interacting with hsa-miR-375 to regulate the tumor suppressor gene SOX17. Increased ENSG00000279204 expression can upregulate SOX17 and is associated with decreased growth and improve outcomes in breast cancer models, highlighting its drug target potential in ceRNA networks of cancer biology[1]. There is still limited clinical evidence and characterization outside computational and preclinical investigations. This lncRNA is primarily annotated by its Ensembl identifier, with no alternative gene symbol or name established in major genomic databases[3]. Notes: - ENSG00000279204 is a non-coding RNA, and as such is not a receptor, enzyme, transporter, or classical protein target. Its function is regulatory within RNA networks. - Its canonical identifier is the Ensembl gene ID, as there is no approved HGNC symbol or standardized functional name[3]. - Literature describes it as a promising experimental target in ceRNA-mediated cancer therapy, specifically for breast cancer[1].

Other names

lncRNA ENSG00000279204

ceRNA crosstalk: Competes for binding to hsa-miR-375, thereby modulating availability of this miRNA to regulate SOX17 expression, which plays a role in breast tumor growth and prognosis