Long non-coding RNA for programmed cell death 5 and p53 stability (LNPPS)

Long non-coding RNA for programmed cell death 5 and p53 stability (LNPPS) is a long non-coding RNA transcript (ENST00000622374) discovered in the context of bladder cancer. LNPPS acts as a scaffold, physically connecting PDCD5 and the tumor suppressor protein p53 via distinct nucleotide regions, thereby enhancing their interaction. This lncRNA protects PDCD5 from proteasomal degradation by masking its ubiquitination at K20, and disrupts MDM2-mediated ubiquitination of p53, increasing p53 stability and promoting apoptosis. LNPPS is typically downregulated in bladder cancer tissues due to reduced N6-methyladenosine (m6A) modification, contributing to tumor survival. Restoration or enhancement of LNPPS expression in cancer cells leads to upregulation of p53 and activation of apoptosis pathways, marking it as a potent tumor suppressor and a potential therapeutic target for bladder cancer and possibly other malignancies where the PDCD5/p53 axis plays a role[1][3].

Other names

LNPPSlncRNA PDCD5 and p53 scaffolda lncRNA for programmed cell death 5 (PDCD5) and p53 stability

Scaffold-mediated inhibition of ubiquitination (prevents PDCD5 ubiquitination at K20, impairs MDM2-mediated ubiquitination of p53), Stabilization of p53 and PDCD5, Activation of p53-dependent apoptosis