Long non-coding RNA Loc490 (Loc490)

Long non-coding RNA Loc490 (QKILA) is a regulatory RNA molecule downregulated in gastric cancer and lymph node metastases compared to normal tissue. Loc490 binds and stabilizes the RNA-binding protein QKI, which suppresses EMT-associated proteins and inhibits gastric cancer cell proliferation, invasion, and metastasis. Its expression is positively correlated with QKI levels and favorable clinical outcomes. Experimental evidence indicates Loc490’s tumor-suppressing functions depend on its interaction with QKI, primarily altering QKI protein stability and downstream targets in the EMT pathway. It represents a potential therapeutic target and prognostic biomarker for gastric cancer, with ongoing research into activating its expression for cancer treatment[1][3].

Other names

QKI interacting lncRNAQKILALoc490LOC101927490

Post-translational stabilization of QKI, leading to inhibition of EMT-related proteins (e.g., N-cadherin, MMP-9, Vimentin) and upregulation of E-cadherin; Direct RNA-protein binding at specific sites on Loc490 (nucleotides 760-778 and 860-869)