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Long Non-coding RNA-Protein Interaction

Molecular classification: Non-coding RNA-protein complex, Scaffold, Transcription factor regulator, Epigenetic regulator

Overview

Long non-coding RNA–protein interactions constitute a fundamental mechanism through which cells regulate genetic programs beyond protein coding genes. Their complexity offers both challenges and opportunities for biomedical research and therapeutic intervention. LncRNAs act as scaffolds, guides, decoys, and regulators of transcriptional machinery, influencing diverse biological processes from epigenetic regulation to signal transduction. These interactions occur in both the nucleus and cytoplasm and are implicated in various diseases, including cancer.

Other names: lncRNA-protein complexlncRNA interactome

Biological functions

Regulation of gene expressionEpigenetic regulationTranscriptional regulationPost-transcriptional regulationChromatin remodelingSignal transduction

Disease associations

CancerDevelopmental disorders

Safety considerations

Off-target effects due to complex interactionsDelivery challenges for RNA-based therapeutics

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