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Target intelligence / Profile preview
Long non-coding RNA receptor tyrosine kinase-like orphan receptor 1 antisense RNA 1 (ROR1-AS1)
- Target
- ROR1-AS1
- Molecular classification
- Long non-coding RNA, Antisense RNA, Other
01
Overview
Long non-coding RNA receptor tyrosine kinase-like orphan receptor 1 antisense RNA 1 (ROR1-AS1) is a long noncoding RNA (lncRNA), located at chromosome 1p31.3, transcribed antisense to the ROR1 gene. ROR1-AS1 is overexpressed in various cancers, including hepatocellular carcinoma and mantle cell lymphoma, where it is associated with advanced tumor stage, lymph node metastasis, and poorer prognosis[2][5]. Functional studies and network analyses implicate ROR1-AS1 in the regulation of epithelial-mesenchymal transition, cell proliferation, integrin binding, Wnt/β-catenin and PI3K-AKT signaling pathways, as well as cytosolic ribosomes and cell substrate junctions[2][5]. High ROR1-AS1 expression is an independent unfavorable prognostic factor in hepatocellular carcinoma and may serve as a biomarker for cancer diagnosis and prognosis[2][5]. It is currently classified as a regulatory non-coding RNA and not as a direct therapeutic target or conventional receptor, enzyme, or transporter. There are no reported direct drug interactions or specific therapeutic agents targeting ROR1-AS1, nor are there established safety concerns unique to this molecule.
- Other names
- THE1B/ROR1-ASROR1-ASROR1 antisense RNA 1
02
Biological functions
Regulation of gene expressionModulation of cell proliferationRegulation of cell migration and invasionPositive regulation of Wnt signaling pathwayInvolvement in epithelial-mesenchymal transitionRegulation of prognosis in cancer
03
Disease associations
Cancer (including hepatocellular carcinoma, mantle cell lymphoma, and possibly others)Other (as implicated in tumorigenesis broadly)
04
Biomarkers
Prognostic biomarker in hepatocellular carcinomaBiomarker for cancer progression and poor outcome
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