Long non-coding RNA transcript (lncRNA)

A **long non-coding RNA transcript (lncRNA)** is an RNA molecule typically longer than 200 nucleotides that is not translated into protein[1][7][9]. lncRNAs are a diverse group of transcripts transcribed by RNA polymerase II, and include various subtypes such as intergenic, intronic, sense, and antisense lncRNAs[1][4]. They are involved in the regulation of gene expression on multiple levels (epigenetic, transcriptional, post-transcriptional), chromatin organization, maintenance of genomic stability, and in cellular responses to external stimuli[3][4][5][6][8]. Dysregulated lncRNA expression has been implicated in numerous diseases, including cancers, neurodegenerative and cardiovascular disorders, and immune-related conditions[3][4][5]. While individual lncRNAs (e.g., HOTAIR, MALAT1, Xist) can serve as important biomarkers or therapeutic targets, "long non-coding RNA transcript" refers generically to a class of molecules and not to a specific targetable entity[3][6][9].

Other names

long ncRNAlncRNAlong noncoding RNAlarge intergenic non-coding RNA (lincRNA)long intervening non-coding RNA