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Target intelligence / Profile preview
Low Affinity Immunoglobulin Epsilon Fc Receptor (CD23)
- Target
- CD23
- Molecular classification
- Receptor, Type II transmembrane glycoprotein, C-type lectin superfamily
01
Overview
CD23 is the low-affinity receptor for IgE antibodies. It is a type II transmembrane glycoprotein involved in regulating IgE levels, antigen presentation, cell adhesion, and immune modulation. It plays a central role in allergic diseases and may be a therapeutic target for allergic and autoimmune conditions. Soluble forms of CD23 (sCD23) can bind IgE and have cytokine-like activities.
- Other names
- Fc epsilon RIIFcεRIIFCER2
02
Mechanism of action
Anti-CD23 antibodies (potential therapeutic strategy); Modulation of allergic inflammation/autoimmune responses (potential therapeutic strategy)
03
Biological functions
Regulation of IgE levelsAntigen presentationCell adhesionImmune modulation
04
Disease associations
Allergic diseasesAutoimmune conditions
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